1928 2017
Knut Aukland
in Interstitium
Norwegian physiologist (1928–2017). Professor of Physiology at the University of Bergen for over four decades and the founding figure of what became the Bergen school of microvascular and interstitial-fluid physiology. MD/PhD from the University of Oslo; built the Bergen physiology programme into one of the internationally significant centres for capillary-and-interstitial fluid mechanics. Trained two generations of Norwegian microcirculation physiologists including Rolf Reed and Helge Wiig.
Stake§
Aukland's stake was scientific and institutional — the long arc of building a regional physiology programme that produced authoritative reviews and trained a continuing succession of researchers. No commercial entanglements; the work was funded through the Norwegian Research Council and university channels. The Bergen programme's reputation in the interstitial-fluid field is largely his legacy.
The 1993 Physiological Reviews synthesis with Rolf Reed is Aukland's most-cited single piece, but it is the synthesis statement of a primary-research career stretching back into the 1950s on transcapillary exchange, oncotic pressure, and the regulation of tissue fluid volume. The Bergen school's characteristic method — careful direct measurement of capillary pressures and interstitial fluid properties using micropipettes and direct cannulation techniques — was largely Aukland's methodological contribution to the field.
The institutional contribution may be more significant than any single paper. The Bergen physiology programme produced a continuing succession of researchers — Reed as the immediate successor, Wiig in the following generation — and the 2012 Physiological Reviews update by Wiig and Swartz is in important ways the continuation of the 1993 review and the broader Aukland programme.
Aukland belongs in the careful-physiology tradition — the slow basic-science work that produces the kind of authoritative reviews that subsequent fields rest on. The Mestres- Ventura 2019 critique of the Benias unrecognised framing draws much of its force from this lineage: the interstitium was extensively characterised by the Bergen school decades before the 2018 imaging put it in the popular press.