Interstitium
The recently re-described fluid-filled compartment within and between human tissues — collagen-supported sinuses draining to lymph, present in the submucosae, dermis, peri-bronchial and peri-arterial soft tissues, and fascia. Probe-based confocal laser endomicroscopy made them visible in vivo where standard slide- preparation had collapsed them. A reading list around four threads: the original Benias 2018 finding and its published debate (Mestres-Ventura 2019 commentary, Benias 2019 reply, Cenaj-Theise 2021 continuity follow-up); the pre-modern fluid-physiology foundation (Aukland and Reed 1993, Wiig and Swartz 2012); the cancer-microenvironment programme (Heldin et al. 2004 on tumour interstitial pressure, Swartz and Lund 2012 on flow-and-immunity, Munson on glioblastoma); and the adjacent literatures — fascia and connective tissue (Stecco; Langevin and Yandow 2002 primary correlation of acupuncture meridians to connective-tissue planes, Langevin 2006 signalling hypothesis), the brain's glymphatic system and meningeal lymphatics (Iliff 2012, Xie 2013 on sleep- driven clearance, Louveau 2015 on the rediscovered CNS lymphatic vessels), and the mechanotransduction underpinning (Engler-Discher 2006 on matrix elasticity directing cell fate). Theise's 2023 *Notes on Complexity* is the intellectual frame within which the *system, not organ* characterisation makes sense.
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◊ concepts
❡ people
Adam J. Engler · Antoine Louveau · Carl-Henrik Heldin · Dennis E. Discher · Helene Langevin · Helge Wiig · Jeffrey J. Iliff · Jonathan Kipnis · Knut Aukland · Maiken Nedergaard · Melody A. Swartz · Neil Theise · Odise Cenaj · Pedro Mestres-Ventura · Petros Benias · Rolf K. Reed
§ sources
- Interstitial-lymphatic mechanisms in the control of extracellular fluid volume
- Structure and Distribution of an Unrecognized Interstitium in Human Tissues
- Reply to 'Commentaries on the publication entitled: Structure and distribution of an unrecognized interstitium in human tissues by Benias et al. (2018)'
- Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans
- Matrix elasticity directs stem cell lineage specification
- High interstitial fluid pressure — an obstacle in cancer therapy
- A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
- Connective tissue: a body-wide signaling network?
- Relationship of acupuncture points and meridians to connective tissue planes
- Structural and functional features of central nervous system lymphatic vessels
- Commentaries on the publication entitled: 'Structure and distribution of an unrecognized interstitium in human tissues' by Benias et al. (2018)
- Interstitial fluid flow in cancer: implications for disease progression and treatment
- Functional Atlas of the Human Fascial System
- Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
- Notes on Complexity: A Scientific Theory of Connection, Consciousness, and Being
- Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer
- Sleep drives metabolite clearance from the adult brain